Journal
EUROPEAN JOURNAL OF CANCER
Volume 44, Issue 17, Pages 2615-2622Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.08.010
Keywords
CRC; Infusional/oral administration; routes; Direct medical costs
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Aim: To describe the healthcare resource consumption of metastatic colorectal cancer (MCRC) patients in the Italian healthcare setting. Methods: A retrospective chart analysis estimating direct medical costs of first-line infusional 5-Fluorouracil (5-FU) or oral Capecitabine (CAP), associated or not with other chemotherapies, from the Italian Healthcare Service (IHCS) and Hospital (H) perspectives. Results: 202 subjects were analysed. CAP patients (N = 66) were older, with a more compromised clinical status and received less chemotherapy agents in association than 5-FU patients (N = 136). From the IHCS perspective, mean total costs per patient were is an element of 12,029 and is an element of 5,781 in the 5-FU and CAP arms respectively; is an element of 7,338 and is an element of 4,688 from the H perspective. The infusional administration route of 5-FU was a cost driver from both perspectives. Sensitivity analyses found the results to be robust to variations in base case parameters. Conclusions: Management of MCRC by oral chemotherapies may be an economically advantageous option to both IHCS and hospitals. (C) 2008 Elsevier Ltd. All rights reserved.
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