Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 153, Issue -, Pages 35-44Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2015.07.008
Keywords
Obesity; Aromatase; Breast cancer; Adipose; Stromal cells
Funding
- NHMRC (Australia) [GNT1005735, GNT1007714]
- National Breast Cancer Foundation [NC-14-011]
- Victorian Government Operational Infrastructure Support Program
- National Breast Cancer Foundation [NC-14-011] Funding Source: researchfish
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The number of breast cancer cases has increased in the last a few decades and this is believed to be associated with the increased prevalence of obesity worldwide. The risk of breast cancer increases with age beyond menopause and the relationship between obesity and the risk of breast cancer in postmenopausal women is well established. The majority of postmenopausal breast cancers are estrogen receptor (ER) positive and estrogens produced in the adipose tissue promotes tumor formation. Obesity results in the secretion of inflammatory factors that stimulate the expression of the aromatase enzyme, which converts androgens into estrogens in the adipose tissue. Evidence demonstrating a link between obesity and breast cancer has led to the investigation of metabolic pathways as novel regulators of estrogen production, including pathways that can be targeted to inhibit aromatase specifically within the breast. This review aims to present some of the key findings in this regard. (C) 2015 Elsevier Ltd. All rights reserved.
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