Journal
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
Volume 109, Issue 2, Pages 323-330Publisher
SPRINGER
DOI: 10.1007/s00421-010-1353-6
Keywords
Endurance exercise; Chronic training and racing; Skeletal muscle DNA telomere length
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Funding
- University of Cape Town
- South African Medical Research Council
- Association Francais contre les Myopathies
- AFLD
- Inserm. Universite Pierre et Marie Curie
- EU NoE Myores and EU Network Myoage
- University Scholarships Committee Award
- Benfara Scholarship
- Waddell Scholarship
- KW Johnston Bequest Scholarship
- Marion Beatrice Waddell Scholarship
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Measuring the DNA telomere length of skeletal muscle in experienced endurance runners may contribute to our understanding of the effects of chronic exposure to endurance exercise on skeletal muscle. This study compared the minimum terminal restriction fragment (TRF) length in the vastus lateralis muscle of 18 experienced endurance runners (mean age: 42 +/- A 7 years) to those of 19 sedentary individuals (mean age: 39 +/- A 10 years). The runners had covered almost 50,000 km in training and racing over 15 years. Minimum TRF lengths measured in the muscle of both groups were similar (P = 0.805) and within the normal range. Minimum TRF length in the runners, however, was inversely related to their years spent running (r = -0.63, P = 0.007) and hours spent training (r = -0.52, P = 0.035). Therefore, since exposure to endurance running may influence minimum TRF length, and by implication, the proliferative potential of the satellite cells, chronic endurance running may be seen as a stressor to skeletal muscle.
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