Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 154, Issue -, Pages 32-38Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2015.06.010
Keywords
Female reproductive tract; Female reproductive tract pathology; Cancer; Infertility; Endometriosis; Steroid receptor coactivators
Funding
- National Institutes of Health [CA-77530, HD008188, HD-07857]
- Department of Defense [USAMRMC BC122115]
- Cancer Prevention Research Institute of Texas [CPRIT: RP101499]
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The steroid receptor coactivators (SRCs/p160/NCOA) are a family of three transcriptional coregulators initially discovered to transactivate the transcriptional potency of steroid hormone receptors. Even though SRCs were also found to modulate the activity of multiple other transcription factors, their function is still strongly associated with regulation of steroid hormone action and many studies have found that they are critical for the regulation of reproductive biology. In the case of the female reproductive tract, SRCs have been found to play crucial roles in its physiology, ranging from ovulation, implantation, to parturition. Not surprisingly, SRCs' action has been linked to numerous abnormalities and debilitating disorders of female reproductive tissues, including infertility, cancer, and endometriosis. Many of these pathologies are still in critical need of therapeutic intervention and proof-of-principle studies have found that SRCs are excellent targets in pathological states. Therefore, small molecule modulators of SRCs' activity could be applied in the future in the treatment of many diseases of the female reproductive system. (C) 2015 Elsevier Ltd. All rights reserved.
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