Journal
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Volume 26, Issue 10, Pages 807-820Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EJA.0b013e32832d6b0f
Keywords
anaesthetic mechanisms; anaesthetic targets; anaesthetics; ion channels; receptors
Categories
Funding
- US National Institutes of Health [GM58149]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM058149] Funding Source: NIH RePORTER
Ask authors/readers for more resources
General anaesthesia is administered each day to thousands of patients worldwide. Although more than 160 years have passed since the first successful public demonstration of anaesthesia, a detailed understanding of the anaesthetic mechanism of action of these drugs is still lacking. An important early observation was the Meyer-Overton correlation, which associated the potency of an anaesthetic with its lipid solubility. This work focuses attention on the lipid membrane as a likely location for anaesthetic action. With the advent of cellular electrophysiology and molecular biology techniques, tools to dissect the components of the lipid membrane have led, in recent years, to the widespread acceptance of proteins, namely receptors and ion channels, as more likely targets for the anaesthetic effect. Yet these accumulated data have not produced a comprehensive explanation for how these drugs produce central nervous system depression. In this review, we follow the story of anaesthesia mechanisms research from its historical roots to the intensely neurophysiological research regarding it today. We will also describe recent findings that identify specific neuroanatomical locations mediating the actions of some anaesthetic agents. Eur JAnaesthesiol 26:807-820 (C) 2009 European Society of Anaesthesiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available