Journal
EUROPEAN HEART JOURNAL
Volume 35, Issue 26, Pages 1719-+Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/eht565
Keywords
Central pressure; Blood pressure; Anti-hypertensive treatment; Cardiovascular risk
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Funding
- National Institute for Health Research Cambridge Biomedical Research Centre
- National Institute of Health
- British Heart Foundation [FS/12/8/29377] Funding Source: researchfish
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Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular risk. However, systolic pressure varies throughout the arterial tree, such that aortic (central) systolic pressure is actually lower than corresponding brachial values, although this difference is highly variable between individuals. Emerging evidence now suggests that central pressure is better related to future cardiovascular events than is brachial pressure. Moreover, anti-hypertensive drugs can exert differential effects on brachial and central pressure. Therefore, basing treatment decisions on central, rather than brachial pressure, is likely to have important implications for the future diagnosis and management of hypertension. Such a paradigm shift will, however, require further, direct evidence that selectively targeting central pressure, brings added benefit, over and above that already provided by brachial artery pressure.
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