Journal
EUROPEAN HEART JOURNAL
Volume 30, Issue 8, Pages 890-899Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehp078
Keywords
Endothelial progenitor cells; Bone marrow-derived stem cells; Acute myocardial infarction; Stem cell mobilization
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Funding
- Fondazione Cassa di Risparmio di Roma to UNICATT Cord Blood Bank
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Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.
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