Journal
EUROPEAN HEART JOURNAL
Volume 29, Issue 6, Pages 800-809Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehn049
Keywords
C-reactive protein; lipids; prediction of mortality in old age
Categories
Funding
- British Heart Foundation Funding Source: Medline
- Medical Research Council [MC_U137686857] Funding Source: Medline
- Wellcome Trust [082178] Funding Source: Medline
- MRC [MC_U137686857] Funding Source: UKRI
- Medical Research Council [MC_U137686857] Funding Source: researchfish
Ask authors/readers for more resources
Aims To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. Methods and results The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after adjustment for each other [fully adjusted HRs: 1.60 (lnCRP); 1.01 (fibrinogen); 0.61 (albumin)]. Higher CRP and lower albumin levels were also associated with significantly raised non-vascular mortality independently of other characteristics [fully adjusted HRs: 1.62 (lnCRP); 0.65 (albumin)]. Conclusion In this cohort of older men, higher CRP and lower albumin levels strongly predicted both vascular and non-vascular mortality, independently of other characteristics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available