Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 40, Issue 11, Pages 1259-1270Publisher
SPRINGER
DOI: 10.1007/s00249-011-0713-4
Keywords
Prion protein; Zinc; Copper; XAS spectroscopy; Metal homeostasis
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Funding
- NIGMS NIH HHS [R01 GM065790] Funding Source: Medline
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In this work we present and analyse XAS measurements carried out on various portions of Prion-protein tetra-octa-repeat peptides in complexes with Cu(II) ions, both in the presence and in the absence of Zn(II). Because of the ability of the XAS technique to provide detailed local structural information, we are able to demonstrate that Zn acts by directly interacting with the peptide, in this way competing with Cu for binding with histidine. This finding suggests that metal binding competition can be important in the more general context of metal homeostasis.
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