Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 38, Issue 8, Pages 1061-1068Publisher
SPRINGER
DOI: 10.1007/s00249-009-0509-y
Keywords
Ca2+ spiral waves; Ion channel; Random medium
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Funding
- National Natural Science Foundation of China [10875049, 10747005]
- Chinese Ministry of Education [108096]
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It is well known that the spatial distribution of the calcium ion channels in the endoplasmic reticulum is discrete. We study the Ca2+ spiral pattern formation based on a model in which ion channels are discretely and randomly distributed. Numerical simulations are performed on different types of media with the Ca2+ release sites uniformly distributed, discretely and uniformly arranged, or discretely and randomly arranged. The comparisons among the different media show that random distribution is necessary for spontaneous initiation of Ca2+ spiral waves, and the discrete and random distribution is of significance for spiral waves under physiologically reasonable conditions. The period and velocity of spiral waves are also calculated, and they are not prominently changed by varying the type of medium.
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