Journal
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
Volume 263, Issue 5, Pages 379-384Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00406-012-0369-9
Keywords
Autistic disorder; Youth; Magnetic resonance spectroscopy; Glutamate
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Funding
- Pediatric Psychopharmacology Council Fund
- Norma Fine Pediatric Psychopharmacology Fellowship Fund
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The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 +/- A 1.8; age range: 12-17 years) with intact intellectual capacity (mean IQ: 108 +/- A 14.26; IQ range: 85-127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic disorder versus control subjects (paired t test p = 0.01) and a trend for lower Glu in the right medial temporal lobe, which was not statistically different between the groups (paired t test p = 0.06). These preliminary findings support the glutamatergic dysregulation hypothesis in autism and need to be replicated in a larger sample.
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