Journal
EUROPACE
Volume 14, Issue 10, Pages 1475-1482Publisher
OXFORD UNIV PRESS
DOI: 10.1093/europace/eus069
Keywords
Sick sinus syndrome; Sinoatrial node; Pacemakers; Heart failure; Pacing
Categories
Funding
- Medtronic
- St Jude Medical
- Biotronik
- Boston Scientific
- Ela Medical
- Pfizer
- Danish Heart Foundation [10-04-R78-A2954-22779]
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Aims Previous studies indicate that ventricular pacing may precipitate heart failure (HF). We investigated occurrence of HF during long-term follow-up among patients with sick sinus syndrome (SSS) randomized to AAIR or DDDR pacing. Furthermore, we investigated effects of percentage of ventricular pacing (%VP) and pacing site in the ventricle. Methods and results We analysed data from 1415 patients randomized to AAIR (n = 707) or DDDR pacing (n = 708). Ventricular pacing leads were recorded as located in either an apical or a non-apical position. The %VP and HF hospitalizations were recorded during follow-up. Patients were classified with new HF, if in New York Heart Association (NYHA) functional class IV or if presence of >= 2 of: oedema; dyspnoea; NYHA functional class III. Mean follow-up was 5.4 +/- 2.4 years. Heart failure hospitalizations did not differ between groups. In the AAIR group, 170 of the 707 (26%) patients developed HF vs. 169 of the 708 (26%) patients in the DDDR group, hazard rate ratio (HR) 1.00, 95% confidence interval (Cl) 0.79-1.22, P = 0.87. In DDDR patients, 146 of the 512 patients (29%) with ventricular leads in an apical position developed HF vs. 28 of the 161 patients (17%) with the leads in a non-apical position, HR 0.67, Cl 0.45-1.00, P = 0.05. After adjustments this difference was non-significant. The incidence of HF was not associated with %VP (P = 0.57). Conclusion In patients with SSS, HF was not associated with pacing mode, %VP, or ventricular lead localization. This suggests that DDDR pacing is safe in patients with SSS without precipitating HF.
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