Journal
EUROPACE
Volume 10, Issue 12, Pages 1364-1369Publisher
OXFORD UNIV PRESS
DOI: 10.1093/europace/eun271
Keywords
Calcium; Cardiac myocyte; Sarcoplasmic reticulum; Na/Ca exchange; Arrhythmias; Ryanodine receptor; SERCA
Categories
Funding
- FWO [G.0384.07]
- European Union [LSHM-CT-2005-018833]
- Belgian Science Program [IAP6/31]
Ask authors/readers for more resources
Abnormal calcium (Ca) handling can contribute to arrhythmogenesis directly by triggering abnormal depolarizations and indirectly by modulating action potential time course and duration. Recent data have shown the importance of these mechanisms in rare genetic diseases but also in more common conditions such as heart failure. Modulating Ca release from the sarcoplasmic reticulum via the ryanodine receptor, Ca uptake via sarcoplasmic reticulum Ca ATPase or Ca removal from the cell via the Na/Ca exchanger, are potential approaches to reduce arrhythmias. New tools allow exploring these ideas. The principles underlying this approach and the first results are critically reviewed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available