Journal
EUKARYOTIC CELL
Volume 10, Issue 9, Pages 1264-1268Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.05138-11
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Funding
- NIH NIAID [R01AI072195, R01AI050184]
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Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.
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