Journal
EUKARYOTIC CELL
Volume 9, Issue 3, Pages 472-476Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.00378-09
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Funding
- Faculty of Medicine-Siriraj Hospital Fellowship
- American Society for Transplantation
- Children's Miracle Network
- [A1061149]
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The Aspergillus fumigatus Delta pmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.
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