3.9 Article

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

Journal

EUKARYOTIC CELL
Volume 8, Issue 11, Pages 1803-1807

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.00240-09

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Funding

  1. National Institutes of Health

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Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

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