Journal
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
Volume 77, Issue 3, Pages 610-619Publisher
SPRINGER
DOI: 10.1007/s10971-015-3890-2
Keywords
Alginate; Microdroplets; Microparticles; Collision; Gelation
Categories
Funding
- Science Fund for Creative Research Groups of National Natural Science Foundation of China [51221004]
- National Natural Science Foundation of China [51375440]
- Public Technology Research Program of Zhejiang Province [2014C31G2010157]
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Drop-on-demand jetting was combined with a gelation technique to fabricate alginate microparticles into varied shapes. First, uniform alginate microdroplets were generated by adjusting the parameters of the voltage waveform which is applied to a piezoelectric print-head. Next, the alginate microdroplets were solidified by calcium ions, resulting in the formation of alginate microparticles. The collision of alginate microdroplets with the surface of CaCl2 solution and a cross-linking reaction caused formation of microparticles of spherical, elliptical, tail-shaped, and other shapes. The effect of printing parameters including microdroplet velocity and concentration of CaCl2 solution on microparticle shape was systematically studied. We found that tail-shaped microparticles were better to form lines compared to spherical microparticles. Our findings can guide efforts for more precise fabrication of differently shaped alginate microparticles using drop-on-demand jetting for application in bioprinting, drug delivery, and cell encapsulation. [GRAPHICS] .
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