Journal
AUTOPHAGY: MOLECULES AND MECHANISMS
Volume 55, Issue -, Pages 17-27Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSE0550017
Keywords
Beclin1; omegasome; PI3P; ULK complex; Vps34
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Funding
- BBSRC [BB/H000631/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0413, BB/H000631/1] Funding Source: Medline
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Autophagy is a conserved survival pathway, which cells and tissues will activate during times of stress. It is characterized by the formation of double-membrane vesicles called autophagosomes inside the cytoplasm. The molecular mechanisms and the signalling components involved require specific control to ensure correct activation. The present chapter describes the formation of autophagosomes from within omegasomes, newly identified membrane compartments enriched in PI3P (phosphatidylinositol 3-phosphate) that serve as platforms for the formation of at least some autophagosomes. We discuss the signalling events required to nucleate the formation of omegasomes as well as the protein complexes involved.
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