Journal
ACS NANO
Volume 9, Issue 8, Pages 7925-7939Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b00042
Keywords
iron oxide nanoparticles; gold nanoparticles; heterostructure; aging; degradation; elimination; biodistribution; nanotoxicity
Categories
Funding
- ANR (Agence Nationale de la Recherche)
- CGI (Commissariat a l'Investissement d'Avenir) through Labex SEAM (Science and Engineering for Advanced Materials and devices) [ANR 11 LABX 086, ANR 11 IDEX 05 02]
- European project Magnifyco [NMP4-SL-2009-228622]
- Region Ile de France for convention SESAME [E1845]
- CNRS (Defi Nano)
- DIM C'Nano Ile de France
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Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.
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