Journal
EPILEPSY RESEARCH
Volume 98, Issue 2-3, Pages 264-268Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2011.09.016
Keywords
Cerebral edema; Magnetic resonance imaging; Seizure; Status epilepticus; Water channels
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Funding
- NINDS NIH HHS [K08 NS059674] Funding Source: Medline
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We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6 h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and 12 MRI changes in AQP4(-/-) compared to AQP4(+/+) mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity. (C) 2011 Elsevier B.V. All rights reserved.
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