Journal
EPILEPSY RESEARCH
Volume 96, Issue 1-2, Pages 116-122Publisher
ELSEVIER
DOI: 10.1016/j.eplepsyres.2011.05.011
Keywords
Intracranial; EEG; Canine; Epilepsy device
Categories
Funding
- Epilepsy Foundation
- NIH [R01-NS063039, 1U24NS063930-01A1, NINDS RO1-NS041811-04, R01 NS 48598-04]
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We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting. (C) 2011 Elsevier B.V. All rights reserved.
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