Journal
EPILEPSY RESEARCH
Volume 85, Issue 2-3, Pages 142-149Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2009.03.005
Keywords
Epileptogenesis; Blood-brain barrier; Astrocytes; Transforming growth factor beta
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Funding
- Sonderforschungsbereich
- Israeli Science Foundation [566/07]
- Binational US-Israel Foundation [BSF 2007185]
- CURE foundation
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Epileptogenesis is common following brain insults such as trauma, ischemia and infection. However, the mechanisms underlying injury-related epileptogenesis remain unknown. Recent studies demonstrated impaired integrity of the blood-brain barrier (BBB) during epileptogenesis. Here we review accumulating experimental evidence supporting the potential involvement of primary BBB lesion in epileptogenesis. Data from animal experiments demonstrate that primary breakdown of the BBB prone animals to develop focal neocortical epilepsy that is followed by neuronal toss and impaired functions. The extravasation of albumin from the circulation into the brain neuropil was found to be sufficient for the induction of epileptogenesis. Albumin binds to transforming growth factor beta receptor 2 (TGF beta R2) in astrocytes and induces rapid transcriptional modifications, astrocytic transformation and dysfunction. We highlight a novel cascade of events which is initiated by increased BBB permeability, eventually leading to neuronal dysfunction, epilepsy and cell loss. We review potential mechanisms and existing experimental evidence for the important role of astrocytes and the TGF beta pathway in epileptogenesis. Finally, we review evidence from human clinical data supporting the involvement of BBB lesion in epilepsy. We propose that primary vascular injury, and specifically BBB breakdown and repair, are key elements in altered interactions within the neurovascular unit and thus may serve as new therapeutic targets. (C) 2009 Elsevier B.V. All rights reserved.
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