Journal
EPILEPSY RESEARCH
Volume 86, Issue 2-3, Pages 221-223Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2009.05.006
Keywords
Traumatic brain injury; Head injury; Controlled cortical impact; Seizures; Immaturity; Development
Categories
Funding
- National Institutes of Health [K12-HD01410-01, NS045144]
- Primary Children's Medical Center Foundation
- University of Utah Children's Health Research Center
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Preclinical models of pediatric posttraumatic epilepsy (PTE) are tacking. We hypothesized that traumatic brain injury (TBI), induced by controlled cortical impact, in immature rats would cause etectroencephatographic (EEG) epileptiform activity and behavioral seizures. TBI or sham craniotomy was performed on postnatal day 17. Using video-EEG monitoring 4-11 months post-TBI, most TBI rats (87.5%) showed EEG spiking and one had spontaneous, recurrent seizures. Controls showed neither EEG spikes nor electrographic/behavioral seizures. Late seizures were rare after TBI, but EEG spiking was common and may represent a surrogate for PTE. (C) 2009 Elsevier B.V. All rights reserved.
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