Antiepileptic drug utilization in Taiwan: Analysis of prescription using National Health Insurance database

Objective: The objective of this study was to analyze and evaluate antiepileptic drug (AED) utilization among adults in Taiwan. Methods: A random sample of 167,377 patients from the National Health Insurance (NHI) reference database was used. Prescription records were retrieved for all patients prescribed AEDs during 2004. The prescribed daily dose/defined daily dose (PDD/DDD) ratio was used to assess the adequacy of AED dosing. Results: Seventy-one percent (n = 518) of patients used only one AED, while 29% (n = 212) used more than two AEDs in 2004. For monotherapy, the most frequent regimens included carbamazepine (41.9%), followed by phenytoin (27.3%) and valproic acid (17.8%). For polytherapy, the most commonly used combination was valproic acid and carbamazepine. For adults, the mean PDD/DDD ratio for each AED used for either monotherapy or polytherapy was less than 1.00. Additionally, adult patients treated with more than one AED during 2004 in Taiwan took each drug in higher dose than patients using the same AED in monotherapy. Conclusion: In Taiwan antiepileptic drug therapies appear to be still dominated by the first generation drugs. The mean dosages of most antiepileptic drugs were lower than that of WHO suggested. (C) 2008 Elsevier B.V. AR rights reserved.