Journal
EPILEPSY RESEARCH
Volume 84, Issue 2-3, Pages 238-241Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2009.01.002
Keywords
Epilepsy; Adenosine; Human mesenchymal stem cells; Cell therapy; Grafting; Silk
Categories
Funding
- NINDS [R01 NS058780]
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A novel generation of silk-based brain implants engineered to release adenosine was recently shown to provide robust seizure suppression in kindled rats. As a first step to develop stem cell-coated silk-based 3D-scaffolds for the therapeutic tong-term delivery of adenosine we engineered human mesenchymal stem cells (hMSCs) to release adenosine. Here we demonstrate reduction of chronic seizures in a mouse model of CA3-selective epileptogenesis after infrahippocampal transplantation of adenosine-releasing hMSCs. (C) 2009 Elsevier B.V. All rights reserved.
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