Journal
EPILEPSY RESEARCH
Volume 78, Issue 2-3, Pages 232-234Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2007.11.001
Keywords
maturation; development; epilepsy
Categories
Funding
- NICHD NIH HHS [K12-HD 01410-01, K12 HD001410, K12 HD001410-01A2] Funding Source: Medline
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Electroconvulsive seizure thresholds were compared between adolescent and mature Sprague-Dawley, Wistar, and Fischer rats. All strains had similar hindbrain or forebrain seizure thresholds as adolescents. As adults, hindbrain or forebrain seizure thresholds were highest for Sprague-Dawley and lowest for Fischer rats. Conversely, limbic seizure thresholds during adolescence were highest for Fischer rats. Additional study is needed to better delineate strain and maturational effects on electroconvulsive seizure testing. (C) 2007 Elsevier B.V. All rights reserved.
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