Journal
JOURNAL OF SEPARATION SCIENCE
Volume 38, Issue 16, Pages 2900-2906Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201400677
Keywords
Capillary electrophoresis; Clarithromycin lactobionate; Cyclodextrin; Dual chiral system; Enantioseparation
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Funding
- National Natural Science Foundation of China [81072610]
- Fundamental Research Funds for the Central Universities [PY2014LX0014]
- Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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In this paper, the use of clarithromycin lactobionate, a kind of antibiotic chiral selector, in combination with four neutral cyclodextrin derivatives (glucose-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, methyl-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin) was reported for the first time. As a result, these dual systems gave much better resolution of nefopam (the Rs increased to 3.58, 2.72, 1.49 and 1.42, respectively) compared to the single systems. The effects of buffer pH and selector concentration on the separation of nefopam were also investigated. Additionally, some other basic drugs including metoprolol, atenolol, propranolol, bisoprolol, esmolol and ritodrine were tested for the investigation and evaluation of the enantiorecognition capability of the four dual systems. As expected, the synergistic effect was observed in four systems. Different results of these dual systems were also summarized.
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