Journal
JOURNAL OF SEPARATION SCIENCE
Volume 38, Issue 4, Pages 556-561Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201401034
Keywords
Chiral stationary phases; Enantioseparation; High-performance liquid chromatography; Homochiral metal-organic frameworks
Categories
Funding
- National Natural Science Foundation of China [21275126, 21127012]
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Metal-organic frameworks are promising porous materials. Chiral metal-organic frameworks have attracted considerable attention in controlling enantioselectivity. In this study, a homochiral metal-organic framework [Co-2(D-cam)(2)(TMDPy)] (D-cam = D-camphorates, TMDPy = 4,4'-trimethylenedipyridine) with a non-interpenetrating primitive cubic net has been used as a chiral stationary phase in high-performance liquid chromatography. It has allowed the successful separation of six positional isomers and six chiral compounds. The good selectivity and baseline separation, or at least 60% valley separation, confirmed its excellent molecular recognition characteristics. The relative standard deviations for the retention time of run-to-run and column-to-column were less than 1.8 and 3.1%, respectively. These results demonstrate that [Co-2(D-cam)(2)(TMDPy)] may represent a promising chiral stationary phase for use in high-performance liquid chromatography.
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