Journal
EPILEPSY & BEHAVIOR
Volume 29, Issue 2, Pages 407-411Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2013.08.033
Keywords
Follow-up study; Birth cohort; Pregnancy; Anticonvulsants; Maternal epilepsy; Strengths and Difficulties Questionnaire; Behavioral development
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Funding
- Danish National Research Foundation
- Pharmacy Foundation
- Egmont Foundation
- March of Dimes Birth Defect Foundation
- Augustinus Foundation
- Health Foundation
- Aarhus University Research Foundation
- Lennart Gram Memorial Foundation
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We studied the association between maternal epilepsy, antiepileptic drug (AED) treatment, and behavioral problems in preschool children. In the Danish National Birth Cohort, we identified 4- to 5-year-old children whose mothers had epilepsy and received AED treatment (n = 133) or not (n = 304) during pregnancy and compared them with randomly selected children whose mothers did not have epilepsy (n = 1193). The children's behavioral problems were assessed by the use of the Strengths and Difficulties Questionnaire (SDQ). Children prenatally exposed to AEDs more often had an abnormal total SDQ score as compared with children of women without epilepsy (odds ratio (OR) = 4.8 (95% CI: 1.9-12.1)) and as compared with children of women with epilepsy who were not treated with AEDs during their pregnancy (OR = 4.0 (95% CI: 1.3-12.8)). In conclusion, prenatal AED exposure may increase the risk of behavioral problems in preschool children even after adjustments for potential confounders and maternal epilepsy. (C) 2013 Elsevier Inc. All rights reserved.
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