Journal
EPILEPSY & BEHAVIOR
Volume 27, Issue 1, Pages 174-187Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2013.01.009
Keywords
Melatonin; Circadian; Kainic acid; Depression; Monoamines; Neuronal damage
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Funding
- Medical Science Council, Medical University, Sofia, Bulgaria [30/2011]
- National Science Fund [DTK 02/56 2009-1012]
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Melatonin is a potent antioxidant which showed anticonvulsant activities both in experimental and clinical studies. In the present study, we examined the effect of melatonin treatment (10 mg/kg/day, diluted in drinking water, 8 weeks) during epileptogenesis on the consequences of a kainate (1(A)-induced status epilepticus (SE) in rats. Melatonin increased the latency in the appearance of spontaneous recurrent seizures (SRSs) and decreased their frequency only during the treatment period. The behavioral alterations associated with hyperactivity, depression-like behavior during the light phase, and deficits in hippocampus-dependent working memory were positively affected by melatonin treatment in rats with epilepsy. Melatonin reduced the neuronal damage in the CA1 area of the hippocampus and piriform cortex and recovered the decrease of hippocampal serotonin (5-HT) level in rats with epilepsy. Taken together, long-term melatonin treatment after SE was unable to suppress the development of epileptogenesis. However, it showed a potential in reducing some of the deleterious alterations that develop during the chronic epileptic state in a diurnal phase-dependent mode. (C) 2013 Elsevier Inc. All rights reserved.
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