Journal
EPILEPSY & BEHAVIOR
Volume 25, Issue 3, Pages 350-357Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2012.07.019
Keywords
Temporal Lobe Epilepsy (TLE); Default mode network (DMN); fMRI; Functional connectivity; Epilepsy psychopathology; Epileptic networks
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Funding
- Epilepsy Foundation of Greater Los Angeles
- California Community Foundation
- NIH-NINDS K23 grant [NS044936]
- Leff Family Foundation
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The default mode network (DMN) is composed of cerebral regions involved in conscious, resting state cognition. The hippocampus is an essential component of this network. Here, the DMN in TLE is compared to control subjects to better understand its involvement in TLE. We performed resting state connectivity analysis using regions of interest (ROIs) in the retrosplenium/precuneus (Rsp/PCUN) and the ventro-medial pre-frontal cortex (vmPFC) in 36 subjects (11 with right TLE, 12 with left TLE, 13 controls) to delineate the posterior and anterior DMN regions respectively. We found reduced connectivity of the posterior to the anterior DMN in patients with both right and left TLE. However, the posterior and anterior networks were found to be individually preserved. Lateralization of TLE affects the DMN with left TLE demonstrating more extensive networks. These DMN changes may be relevant to altered cognition and memory in TLE and may be relevant to right vs. left TLE differences in cognitive involvement. Published by Elsevier Inc.
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