Journal
EPILEPSY & BEHAVIOR
Volume 16, Issue 2, Pages 274-280Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2009.07.035
Keywords
Positron emission tomography; Fluorodeoxyglucose; Seizure; Epilepsy; Temporal lobectomy; Verbal memory; Hippocampus; Asymmetry
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Funding
- Harvard Medical School Scholars in Clinical Science Program [K30 RR022292-07]
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The primary aim of this study was to determine whether hippocampal asymmetries in fluorodeoxyglucose (FDG) uptake on preoperative PET scans would predict post-temporal lobectomy verbal memory (VM) decline in patients with left temporal lobe epilepsy. A quantitative asymmetry index (AI) of uptake values within a hippocampal region of interest (ROI) was defined by an automated technique. No statistically significant effect of the hippocampal AI on the outcome measure, the pre- to postsurgical change in Logical Memory Percent Retention, was evident. Post hoc analyses revealed that AIs of the superior and inferior temporal gyri approached significance, however, with relatively greater left-sided preoperative metabolism predicting better VM outcomes. This finding suggests reorganization of function and/or retained function of remaining tissue. Although hippocampal FDG-PET asymmetries did not significantly predict changes in VM, the predictive value of neocortical AIs should be further explored. Automated ROI parcellation provides a feasible tool for use in such investigations. (C) 2009 Elsevier Inc. All rights reserved.
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