Journal
EPILEPSY & BEHAVIOR
Volume 16, Issue 2, Pages 311-314Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2009.07.040
Keywords
Epilepsy; Cognition; Neuropsychology; Temporal lobe; Resection; Mesiotemporal sclerosis
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Funding
- Intramural NIH HHS [Z01 NS002858-16] Funding Source: Medline
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Objective: The goal of the work described here was to evaluate relationships among resection volume, seizure outcome, and cognitive morbidity after temporal lobectomy for intractable epilepsy. Methods: Thirty patients with mesial temporal sclerosis were evaluated pre- and postoperatively with the Wechsler Adult Intelligence Scale III, Wechsler Memory Scale III, and three-dimensional coronal spoiled gradient recall acquisition MRI. Preoperative whole-brain volumes were calculated with Statistical Parametric Mapping. Resection volume was calculated by manual tracing. Systat was used for statistical analysis. Results: All resections included the temporal tip, at least 1 cm of the superior temporal gyrus, and 3 to 5 cm of the middle and inferior temporal gyri. Left were significantly smaller than right temporal resections. Seizure-free patients had significantly larger resections. Immediate verbal memory was significantly worse after left temporal lobectomy. Surgical outcome and resection volume did not affect postoperative neuropsychological results. Conclusions: Dominant temporal lobe resections are associated with immediate verbal memory deficits Larger resection volume was associated with improved seizure control but not worse cognitive outcome (C) 2009 Published by Elsevier Inc.
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