Journal
JOURNAL OF SEPARATION SCIENCE
Volume 38, Issue 19, Pages 3337-3344Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201500451
Keywords
Antioxidant activity; Fingerprint; Quality control; Salvia miltiorrhiza var. alba; Traditional Chinese medicine
Categories
Funding
- Shandong Provincial Natural Science Foundation, China [ZR2011HM080]
- Independent Innovation Foundation of Shandong University [2010TS054]
- Graduate Education Innovation Program of Shandong Province [SDYY12074]
- Scientific Research Foundation for Returned Scholar [20121707]
- Major Industrial Development of Innovative Drug Project of Shandong Province [2012CX20203]
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Salvia miltiorrhiza Bge. var. alba C. Y. Wu and H.W. Li has wide prospects in clinical practice. A useful comprehensive method was developed for the quality evaluation of S. miltiorrhiza var. alba by three quantitative parameters: high-performance liquid chromatography fingerprint, ten-component contents, and antioxidant activity. The established method was validated for linearity, precision, repeatability, stability, and recovery. Principal components analysis and hierarchical clustering analysis were both used to evaluate the quality of the samples from different origins. The results showed that there were category discrepancies in quality of S. miltiorrhiza var. alba samples according to the three quantitative parameters. Multivariate linear regression was adopted to explore the relationship between components and antioxidant activity. Three constituents, namely, danshensu, rosmarinic acid, and salvianolic acid B, significantly correlated with antioxidant activity, and were successfully elucidated by the optimized multivariate linear regression model. The combined use of high-performance liquid chromatography fingerprint analysis, simultaneous multicomponent quantitative analysis, and antioxidant activity for the quality evaluation of S. miltiorrhiza var. alba is a reliable, comprehensive, and promising approach, which might provide a valuable reference for other herbal products in general to improve their quality control.
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