Journal
EPILEPSIA
Volume 54, Issue -, Pages 78-80Publisher
WILEY-BLACKWELL
DOI: 10.1111/epi.12285
Keywords
NMDA receptor; Receptor trafficking; Status epilepticus; Acute seizures; Cholinergic seizures; Epilepsy; Monotherapy; Hippocampus
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Funding
- Research Service of the Veterans Health Administration
- NINDS [NS13515, NS074926]
- James and Debbie Cho Foundation
- VHA (Career Development Award)
- Los Angeles Biomedical Research Institute
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We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.
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