Journal
EPILEPSIA
Volume 52, Issue -, Pages 21-27Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1528-1167.2010.02907.x
Keywords
Serotonin; Norepinephrine; Glutamate; Depression; Attention deficit hyperactivity disorder; Temporal lobe epilepsy
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Funding
- Glaxo Smith Kline
- Novartis
- Pfizer
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P>A bidirectional relation between depressive disorders and epilepsy has been suggested by several population-based studies and is supported by experimental studies. This article reviews the potential pathogenic mechanisms operant in both disorders that may explain such a relation. These mechanisms include a hyperactive hypothalamic-pituitary-adrenal (HPA) axis and its neuroanatomic and neuropathologic complications, as well as disturbances in serotonergic, noradrenergic, gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmitter systems, all of which may be interrelated.
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