Journal
EPILEPSIA
Volume 52, Issue 4, Pages 841-845Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1528-1167.2011.02991.x
Keywords
Rat; Temporal lobe epilepsy; Status epilepticus; Diffusion tensor imaging; White matter
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Although epilepsy is historically considered a disease of gray matter, recent diffusion tensor imaging (DTI) studies have shown white matter abnormalities in patients with epilepsy. The histopathologic correlate of these findings, and whether they are a cause or consequence of epilepsy, remains unclear. To characterize these changes and their underlying histopathology, DTI was performed in juvenile rats, 4 and 8 weeks after pilocarpine-induced status epilepticus (SE). In the medial corpus callosum (CC), mean diffusivity and axial diffusivity (MD and lambda(1)) as well as a myelin staining were significantly reduced at 4 weeks. Only the lambda(1) decrease persisted at 8 weeks. In the fornix fimbriae (FF), lambda(1) and myelin staining were decreased at both time points, whereas fractional anisotropy (FA) and MD were significantly reduced at 8 weeks only. We conclude that SE induces both transient and chronic white matter changes in the medial CC and FF that are to some degree related to myelin pathology.
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