Journal
EPILEPSIA
Volume 51, Issue -, Pages 2-17Publisher
WILEY
DOI: 10.1111/j.1528-1167.2010.02602.x
Keywords
Antiepileptogenesis; Definitions; Disease or syndrome modification; Status epilepticus; Traumatic brain injury
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS049525] Funding Source: NIH RePORTER
- NINDS NIH HHS [R21 NS049525-01, R21 NS049525, R21 NS049525-02] Funding Source: Medline
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P>Prevention of epileptogenesis is an unmet need in medicine. During the last 3 years, however, several preclinical studies have demonstrated remarkable favorable effects of novel treatments on genetic and acquired epileptogenesis. These include the use of immunosuppressants and treatments that modify cellular adhesion, proliferation, and/or plasticity. In addition, the use of antiepileptic drugs in rats with genetic epilepsy or proconvulsants in acquired epilepsy models has provided somewhat unexpected favorable effects. This review summarizes these studies, and introduces some caveats when interpreting the data. In particular, the effect of genetic background, the severity of epileptogenic insult, the method and duration of seizure monitoring, and size of animal population are discussed. Furthermore, a novel scheme for defining epileptogenesis-related terms is presented.
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