Journal
JOURNAL OF SEPARATION SCIENCE
Volume 38, Issue 16, Pages 2763-2771Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201500438
Keywords
Antibiotics; Artificial receptors; High-performance liquid chromatography; Macroporous polymer monoliths; Molecular imprinting
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Funding
- Russian Scientific Foundation [14-13-00940]
- St. Petersburg State University [12.50.1193.2014]
- Russian Science Foundation [14-13-00940] Funding Source: Russian Science Foundation
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The synthesis of macroporous molecularly imprinted monoliths was performed using the monomers system 2-hydroxyethyl methacrylate-ethylene glycol dimethacrylate and erythromycin as a template. The copolymerization was carried out in situ inside 50 mm x 4.6 mm i.d. stainless-steel tubing. The morphology of the monoliths was examined with scanning electron microscopy. The porous characteristics were determined both from the data of hydrodynamic permeability of monoliths and by means of mercury intrusion porosimetry. The retention parameters of target substance (erythromycin), values of calculated imprinting factors and apparent dynamic dissociation constants were obtained for monoliths prepared with the application of different amount of template (4, 8 and 12 mol%). The separations of the mixtures azithromycin/erythromycin and ciprofloxacin/erythromycin were demonstrated. Additionally, the possibility of erythromycin quantification in human blood plasma was shown.
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