Journal
EPILEPSIA
Volume 50, Issue -, Pages 69-92Publisher
WILEY
DOI: 10.1111/j.1528-1167.2009.02041.x
Keywords
History; Epilepsy; Drug treatment; Antiepileptic drugs; International League Against Epilepsy
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This paper provides a review of the drug treatment of epilepsy from 1909, the year of the foundation of the International League Against Epilepsy (ILAE), to 1958. It was during this period that modern approaches to the medicinal therapy of epilepsy were formulated and many new drugs were introduced. Of these, both phenytoin and phenobarbital continue to be widely used today. This was the period when scientific screening was also introduced into drug discovery. The leading figures in the ILAE played an important role in guiding the evolution of the treatment of epilepsy during this period.
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