Peroxisome proliferator-activated receptor alpha and the ketogenic diet

Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a drug/fatty acid-activated trans cription factor involved in the starvation response, and is thus relevant to the ketogenic diet (KD). This article summarizes research indicating the role of PPAR alpha in central and peripheral nervous system function with particular reference to downstream targets relevant to anticonvulsant action.