Journal
EPILEPSIA
Volume 49, Issue -, Pages 80-82Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1528-1167.2008.01843.x
Keywords
Ketogenic diet; K-ATP channels; Glycolysis; Ketone bodies
Categories
Funding
- NIH/NINDS [R01 NS055031]
- Ellison Family Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS055031] Funding Source: NIH RePORTER
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The ketogenic diet (KD) has shown remarkable efficacy in the treatment of drug-resistant childhood epilepsy. Our understanding of how the KD produces its anticonvulsant and antiepileptogenic effects remains incomplete, which is perhaps not surprising for a biological manipulation as sweeping as dietary change. Several hypotheses focus on ketone bodies, fuel molecules that circulate at millimolar concentrations in the blood of patients on a KD, as causative agents. Here I consider some recent evidence for one such hypothesis, involving a possible role for altered glycolysis and consequent activation of a class of potassium channels called K-ATP channels.
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