Journal
EPILEPSIA
Volume 49, Issue -, Pages 114-116Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1528-1167.2008.01853.x
Keywords
Glioma; Vascularity; Caloric restriction; Ketone bodies; Metabolic control analysis; Angiogenesis; Apoptosis; Inflammation
Categories
Funding
- NIH [HD39722, NS055195, CA102135]
- American Institute of Cancer Research
- Boston College Expense Fund
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD039722] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA102135] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R56NS055195, R01NS055195] Funding Source: NIH RePORTER
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Information is presented on the calorically restricted ketogenic diet (CRKD) as an alternative therapy for brain cancer. In contrast to normal neurons and glia, which evolved to metabolize ketone bodies as an alternative fuel to glucose under energy-restricted conditions, brain tumor cells are largely glycolytic due to mitochondrial defects and have a reduced ability to metabolize ketone bodies. The CRKD is effective in managing brain tumor growth in animal models and in patients, and appears to act through antiangiogenic, anti-inflammatory, and proapoptotic mechanisms.
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