Journal
EPIGENETICS
Volume 8, Issue 10, Pages 1030-1038Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.25865
Keywords
DNA methylation; Parkinson disease; brain; peripheral blood leukocytes; epigenetics; neurodegeneration; genome-wide methylation
Funding
- NIH [NIA-AG08017, AG051331, AG5131, AG18440]
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Parkinson disease (PD) is a multifactorial neurodegenerative disorder with high incidence in the elderly, where environmental and genetic factors are involved in etiology. In addition, epigenetic mechanisms, including deregulation of DNA methylation have been recently associated to PD. As accurate diagnosis cannot be achieved pre-mortem, identification of early pathological changes is crucial to enable therapeutic interventions before major neuropathological damage occurs. Here we investigated genome-wide DNA methylation in brain and blood samples from PD patients and observed a distinctive pattern of methylation involving many genes previously associated to PD, therefore supporting the role of epigenetic alterations as a molecular mechanism in neurodegeneration. Importantly, we identified concordant methylation alterations in brain and blood, suggesting that blood might hold promise as a surrogate for brain tissue to detect DNA methylation in PD and as a source for biomarker discovery.
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