Journal
EPIGENETICS
Volume 8, Issue 4, Pages 361-372Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.24234
Keywords
Set7; Set9; histone modification; epigenetics; chromatin; gene expression; lysine methylation; metabolic memory; p65
Funding
- Juvenile Diabetes Research Foundation International
- Diabetes Australia Research Trust
- National Health and Medical Research Council (NHMRC)
- National Heart Foundation of Australia
- Australian Postgraduate Award
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Posttranslational histone modifications define chromatin structure and function. In recent years, a number of studies have characterized many of the enzymatic activities and diverse regulatory components required for monomethylation of histone H3 lysine 4 (H3K4me) and the expression of specific genes. The challenge now is to understand how this specific chemical modification is written and the Set7 methyltransferase has emerged as a key regulatory enzyme mediating methylation of lysine residues of histone and non-histone proteins. In this review, we comprehensively explore the regulatory proteins modified by Set7 and highlight mechanisms of specific co-recruitment of the enzyme to activating promoters. With a focus on signaling and transcriptional control in disease we discuss recent experimental data emphasizing specific components of diverse regulatory complexes that mediate chromatin modification and reinterpretation of Set7-mediated gene expression.
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