Journal
EPIGENETICS
Volume 8, Issue 8, Pages 796-801Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.25358
Keywords
placenta; DNA methylation; HTR2A; serotonin; developmental origins of disease; neurodevelopment; epigenetic; behavior
Funding
- NIMH NIH HHS [R01 MH094609] Funding Source: Medline
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The serotonin receptor, HTR2A, exhibits placental expression and function and can be controlled through DNA methylation. The relationship between methylation of HTR2A in the placenta and neurodevelopmental outcomes, evaluated using the NICU Network Neurobehavioral Scales (NNNS), was assessed in newborn infants (n = 444). HTR2A methylation was significantly higher in males and marginally higher in infants whose mothers reported tobacco use during pregnancy. Controlling for confounding variables, HTR2A methylation was negatively associated with infant quality of movement (p = 0.05) and positively associated with infant attention (p = 0.0001). These results suggest that methylation of the HTR2A gene can be biologically and environmentally modulated and is associated with key measures of neurodevelopment.
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