Journal
EPIGENETICS
Volume 6, Issue 9, Pages 1068-1077Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.6.9.16683
Keywords
p53; DNA methylation; chromatin; histone modification; CTCF; Wrap53; epigenetics; cancer
Funding
- Direccion General de Asuntos del Personal Academico-Universidad Nacional Autonoma de Mexico [IN203811]
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) [128464, 213029]
- Doctorado en Ciencias Bioquimicas, UNAM
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The p53 tumor suppressor is one of the most studied molecules in cancer research. Despite the fact that there is a detailed understanding involving multiple aspects of the p53-associated biology, many aspects of its transcriptional regulation are still not well clarified. Limited information is available on how the p53 gene is transcriptional and epigenetically regulated. The p53 gene expression is tightly controlled through a variety of transcription factors, miRNAs, its anti-sense RNA Wrap53, the insulator protein CTCF and very likely by other genetic and epigenetic mechanisms. It's the intent of this article to review in depth important aspects concerning the transcriptional regulation of the p53 gene and perhaps serve as a stepping-stone to begin a conceptual change on how future p53 research cab be approached.
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