Journal
EPIGENETICS
Volume 6, Issue 3, Pages 293-299Publisher
LANDES BIOSCIENCE
DOI: 10.4161/epi.6.3.14378
Keywords
DNA methylation; physical activity; peripheral blood
Funding
- University of North Texas School of Public Health
- NIH [P20MD001633, ES009089]
- Institute for Cancer Research
- Joe and Jessie Crump Fund for Medical Education
Ask authors/readers for more resources
Changes in DNA methylation may represent an intermediate step between the environment and human diseases. Little is known on whether behavioral risk factors may modify gene expression through DNA methylation. To assess whether DNA methylation is associated with different levels of physical activity, we measured global genomic DNA methylation using bisulfite-converted DNA and real-time PCR (MethyLight) for LINE-1 in peripheral blood of 161 participants aged 4575 years enrolled in the North Texas Healthy Heart Study and levels of physical activity using an accelerometer (Actigraph GT1M Monitor). We found that individuals with physical activity 26-30 min/day had a significantly higher level of global genomic DNA methylation compared to those with physical activity <= 10 min/day (beta = 2.52, 95% CI: 0.70, 4.35). However, the association was attenuated and became statistically insignificant after multivariate adjustment (beta = 1.24, 95% CI: -0.93, 3.40). There were some suggestions of a positive association between physical activity and global genomic DNA methylation in non-Hispanics (beta = 1.50, 95% CI: -0.08, 3.08) that warrants further investigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available