Journal
EPIDEMIOLOGY AND INFECTION
Volume 143, Issue 8, Pages 1662-1671Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268814002295
Keywords
Diarrhoea; enteric bacteria; enterotoxin; Escherichia coli; travellers' infection
Funding
- World Health Organization's Department of Vaccine Development
- surveillance of children's diarrhoea in Guatemala [V27/181/142]
- SBL Vaccin, Sweden [H681-911-2290]
- Salix, USA [H682-912-2117]
- Netropica [6N-2008]
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Diarrhoea remains a common cause of illness in Guatemala, with children suffering most frequently from the disease. This study directly compared the frequency, enterotoxin, and colonization factor (CF) profiles of enterotoxigenic Escherichia coli (ETEC) strains isolated from children living in a rural community in Guatemala and from Western visitors to the same location during the same seasons, using similar detection methodologies. We found that ETEC accounted for 26% of severe cases of diarrhoea in children requiring hospitalization, 15% of diarrhoea in the community, and 29% of travellers' diarrhoea in visitors staying >= 2 weeks. The toxin and CF patterns of the ETEC strains isolated from both groups differed significantly (P < 0.0005) as determined by chi(2) = 60.39 for CFs and chi(2) = 35 for toxins, while ETEC phenotypes found in Guatemalan children were comparable to those found in children from other areas of the world.
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