Journal
EPIDEMIOLOGY AND INFECTION
Volume 142, Issue 11, Pages 2412-2421Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268813003531
Keywords
Epidemics; influenza A; mathematical modelling; pandemic; Q fever
Funding
- European Centre for Disease Prevention and Control [GRANT/2008/003]
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In 2009 two notable outbreaks, Q fever and the novel influenza A(H1N1)pdm09, occurred in The Netherlands. Using a composite health measure, disability-adjusted life years (DALYs), the outbreaks were quantified and compared. DALYs were calculated using standardized methodology incorporating age-and sex-stratified data in a disease progression model; years lost due to disability and years of life lost were computed by outcome. Nationally, influenza A(H1N1)pdm09 caused more DALYs (24484) than Q fever (5797). However, Q fever was 8 . 28 times more severe [497 DALYs/1000 symptomatic cases (DP1SC)] than A(H1N1)pdm09 (60 DP1SC). The A(H1N1)pdm09 burden is largely due to mortality while the Q fever burden is due primarily to long-term sequelae. Intervention prioritization for influenza should support patients in a critical condition while for Q fever it should target immediate containment and support for patients with long-term sequelae. Burden estimates provide guidance for focusing intervention options during outbreaks of infectious diseases.
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